Big Easy Weight Loss review

What it is

Big Easy Weight Loss is a telemedicine practice based in Metairie, Louisiana. Its sermorelin page says it serves patients in 49 states, while its homepage says all 50, so confirm your state before you book. Its main business is compounded semaglutide and tirzepatide for weight loss, and it also offers NAD+ therapy, sermorelin and physical training. Sermorelin is sold as a nightly injection, either on its own or as a combination package with NAD+. Big Easy often prescribes it alongside a GLP-1 to help preserve lean muscle during weight loss. Its medications come from a named list of 503A and 503B compounding pharmacies.

How it works

You complete a health assessment online, then schedule a consultation. Big Easy stresses that the appointment is with a physician, not a nurse practitioner, physician assistant or intake nurse. The first visit is a 30-minute live phone or video appointment. After that, Big Easy's FAQ describes a 15-minute live follow-up once a quarter, with portal chat to your physician in between. The physician builds the treatment plan, and Big Easy says dosing is based on your labs, health history and goals. Labs are at the physician's discretion, and you can upload results from the past year instead of repeating them. Sermorelin is injected under the skin before bed. The medication ships discreetly with syringes, alcohol pads and instructions. Refills and messages with your care team go through a patient portal. Pharmacy turnaround is currently five to ten days, depending on the pharmacy, and refrigerated medication goes out overnight. Big Easy's homepage says it serves all 50 states, while the sermorelin page says 49, so confirm yours when you sign up.

Pricing transparency

Sermorelin is priced by package and by pharmacy, not by the month. The lowest price is $267 for an 8-week package filled by OptioRx. Twelve-week packages from ProRx or Hallandale cost $399, which works out to the same weekly cost. Hallandale cannot ship to nine states, including California. A sermorelin and NAD+ combination, given as separate injections, costs $469 for eight weeks or $699 for twelve. Every package includes physician care for the length of treatment, all supplies and free shipping. First, you pay $75 for the consultation. Big Easy credits that toward your treatment, or refunds it if you are not a good fit. Big Easy says every 8- and 12-week package can be paid in monthly installments. Your card is charged when the prescription goes to the pharmacy, usually the evening of your appointment. Klarna and Affirm add a 3% surcharge, CareCredit is accepted, and HSA is a payment option at signup. Big Easy does not bill insurance. Prices can change, and the panel shows only what is available in your state.

Branded vs compounded

There is no FDA-approved sermorelin on the US market, so Big Easy's is compounded, and its disclaimer says compounded drugs have not had FDA review for safety, efficacy or quality. What stands out is the pharmacy detail. Each package names the pharmacy that fills it, and a separate page explains the difference between 503B outsourcing facilities and 503A compounding pharmacies. The pages do not state a dose, vial size or concentration, so you cannot tell how much sermorelin an 8-week package holds until the physician prescribes it.

Pros and watch-outs

The evidence behind what Big Easy Weight Loss prescribes

We grade the molecules, not the marketing. Here is what the human data actually shows for each thing on their menu.

• Does sermorelin work? What the trials actually measured

  Sermorelin reliably makes your pituitary release growth hormone. Beyond that the evidence is one placebo-controlled trial in 19 adults from 1997 — lean body mass up in men only, nothing in women, and no effect on sleep in either.

• Is Sermorelin FDA-Approved? The Real Answer

  Sermorelin was FDA-approved once, under a different name, and that approval is gone. What is sold today is compounded — which is legal, but not the same thing as approved.

• Sermorelin for Weight Loss: Zero Published Records Link It to Any GLP-1

  Sermorelin is sold beside semaglutide and tirzepatide almost everywhere, and PubMed returns no record connecting them at all. No trial has measured weight as an outcome.

How Big Easy Weight Loss compares

A few alternatives worth a look, depending on what you’re optimizing for.

• AlphaMD

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  See AlphaMD →
• SLSystem Labs

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  See System Labs →
• LHLuvo Health

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  See Luvo Health →

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