Rylo Health review
By Nora Vance · Updated October 2026
$249 monthly, $183 quarterly
Rylo Health sells sermorelin as a nightly injection for $249 a month with no contract, or $183 a month billed $549 every quarter. Physician review, supplies and two-day shipping are included.
Our verdict
Rylo Health is a simple, well-explained online option for sermorelin. Intake takes five minutes, a physician reviews it within a day, and you can get a refund until you are prescribed. It says every batch is lab-tested, and it names the pharmacy that fills your vial. The quarterly plan is good value, but month to month it is $249.
Disclosure: Sermorelin Picks is reader-supported. Some links below are affiliate links — if you start care through them we may earn a commission, at no extra cost to you. Partners are listed first; a commission never changes what we write about a provider. How we make money.
At a glance
- Category
- sermorelin injections
- Format
- Injection
- From
- $249/mo injection ($183 quarterly)
- Prescription
- Required
- Compounded
- Yes — not FDA-approved
- Availability
- All 50 states
What it is
Rylo Health is a Texas-based online prescription service that sells five treatments: tirzepatide, semaglutide, NAD+, sermorelin and glutathione. Sermorelin comes as a nightly injection under the skin, and no troche or nasal form is offered. Rylo describes it as a peptide that signals your pituitary to release more of your own growth hormone, rather than replacing it. Its about page names two physicians on the care team and says every prescription is filled by VialsRX, a licensed US compounding pharmacy. Rylo itself never handles the medication. It serves all 50 states, and you must be 18 or older.
How it works
You answer about five minutes of questions on your health history, current medications and goals. There is no video call and no lab work. A US-licensed, board-certified physician reviews your answers within 24 hours, often the same day, and decides whether treatment is right for you. If you are prescribed, the pharmacy fills the order and ships it in unmarked packaging with free two-day shipping. Temperature-sensitive medication travels in an insulated box with a cold pack. Syringes and injection supplies come with it and are restocked every month. Your physician sets the dose and adjusts it over time. If you have questions, you can text a real person rather than a chatbot, and Rylo says the care team checks in every month. A damaged, defective or wrong order is replaced or refunded if you report it within seven days.
Pricing transparency
There are two plans. Monthly is $249, about $8.30 a day, with no contract and the option to cancel any month. Quarterly is $183 a month, billed $549 every three months. Rylo says the quarterly plan saves $792 over a year, and the math holds: $66 a month for twelve months. When the page loads, the quarterly price is the one showing, so switch the toggle if you want to pay monthly. Both plans include the medication, supplies, the physician review and shipping, with no membership fee. Rylo also says the price stays the same at every dose and every refill, so a dose change does not raise your bill. You can cancel with one button in your patient portal or by messaging support, with no cancellation fee. Your current month's shipment is still sent before the cancellation takes effect, so cancel early if you want to avoid the next charge. An order not yet compounded or shipped can be canceled for a refund. Dispensed medication generally cannot be refunded.
Branded vs compounded
There is no FDA-approved sermorelin on the US market, and Rylo says so on its own product page: compounded sermorelin is not FDA-approved. Rylo's point of difference is testing. It says every batch goes through full chemistry and microbiology labs before shipping. That covers sterility, bacterial endotoxins and potency, so the label matches what is in the vial. That is Rylo's own claim, so ask for the batch results if you want proof. No strength in milligrams is published. Rylo lists mild injection-site redness, swelling or pain as the most common side effect. Headache, flushing, dizziness, nausea and taste changes are less common. It notes that sermorelin is not for people who are pregnant or breastfeeding, or who have active cancer or certain uncontrolled hormone disorders.
Pros and watch-outs
What we like
- Says every batch is tested for sterility, endotoxin and potency
- Names the pharmacy that fills your prescription
- Refundable until you are prescribed
- Five-minute intake, physician review within 24 hours
- Supplies, cold-pack packaging and free two-day shipping included
- Same price at every dose; text a real person for support
Watch-outs
- Monthly is $66 more than quarterly, every month
- The page opens on the quarterly price
- No milligram strength published
- Canceling still sends the current month's shipment
- Shipped medication generally not refundable
Best for
Someone planning to stay on sermorelin for at least three months who wants batch testing, a quick physician review and a clear refund rule.
Who should look elsewhere
Someone trying sermorelin for a single month. That costs $249, and the better rate needs a quarterly commitment.
The evidence behind what Rylo Health prescribes
We grade the molecules, not the marketing. Here is what the human data actually shows for each thing on their menu.
- Is Sermorelin FDA-Approved? The Real Answer
Sermorelin was FDA-approved once, under a different name, and that approval is gone. What is sold today is compounded — which is legal, but not the same thing as approved.
- Reading a Compounding Pharmacy's Certificate of Analysis
A COA is real evidence, tied to federal compounding law. It is also batch-specific and time-specific, and it does not prove what most buyers assume it proves.
How Rylo Health compares
A few alternatives worth a look, depending on what you’re optimizing for.
ARSYNL RxA published price on the format you came for
See ARSYNL Rx →- HealthRX
A published price on the format you came for
See HealthRX → - Strut Health
Comparing formats inside one seller
See Strut Health →
More sermorelin injection sellers reviews: AVARA RxTaurus MedsVigorMedsRex MDRegenCenDr. Gillis' Wellness Center
Reviews & prices
How we assessed this. This review reflects Sermorelin Picks’s own read of Rylo Health’s publicly-stated model — pricing transparency, clinical oversight, medication clarity, and access — against our editorial methodology. We publish no fabricated ratings or first-hand outcomes. A partnership never changes the assessment — see how we make money.
Frequently asked
- How much does sermorelin cost at Rylo Health?
- $249 a month on the monthly plan, or $183 a month billed $549 every three months, as of October 2026.
- Why does Rylo Health show $183 first?
- The quarterly plan is selected when the page loads. Switch to Monthly to see $249, the price without a commitment.
- Can I get a refund from Rylo Health?
- Yes, until you are prescribed. Rylo says orders are fully refundable any time before your first physician consultation. After that, an order that has not been compounded or shipped can still be canceled for a refund.
- How do I cancel Rylo Health?
- With one button in your patient portal, or by messaging support. There are no cancellation fees. The current month's shipment still goes out before the cancellation takes effect.
- Does Rylo Health require a video call?
- No. You answer about five minutes of questions, and a physician reviews them within 24 hours. No lab work is required to start.
- Is Rylo Health's sermorelin FDA-approved?
- No, and Rylo says so on its own page. No FDA-approved sermorelin is sold in the US. Rylo's injection is compounded by VialsRX, a licensed US pharmacy.