There are two different numbers floating around under “sermorelin dosage.” Almost nothing online separates them clearly. There is the dose that was actually tested in a published clinical trial, and the dose a peptide clinic or online seller markets to you. They are not the same number, and conflating them is the single biggest source of confusion in this whole topic.
What is the sermorelin dosage?
The only dose with real adult outcome data behind it is 10 micrograms per kilogram of body weight, injected subcutaneously, nightly — the regimen used in the one positive adult trial [1]. For a 70 kg (154 lb) adult, that works out to roughly 700 micrograms a night. That is higher, not lower, than the flat 200–300 microgram nightly range commonly advertised by commercial sermorelin sellers. That commercial range has never been tested in a controlled trial at all. Read that twice: on a per-kilogram basis, the one trial that showed a real effect used more drug than what is typically marketed, not less. See what that trial actually found for the outcomes behind this dose.
Sermorelin dosage chart: mcg, mL and units
Converting a microgram dose into what you draw into a syringe takes two numbers: the dose, and your vial’s concentration after mixing. Concentration is the milligrams in the vial divided by the milliliters of bacteriostatic water added. Then mL = dose in mcg ÷ concentration in mcg per mL, and on a U-100 insulin syringe, units = mL × 100. A 6 mg vial mixed with 3 mL of water holds 2,000 mcg per mL, so a 300 mcg dose is 0.15 mL, which is 15 units.
| Dose | 3 mg vial + 3 mL (1,000 mcg/mL) | 6 mg vial + 3 mL (2,000 mcg/mL) | 9 mg vial + 3 mL (3,000 mcg/mL) |
|---|---|---|---|
| 200 mcg | 0.2 mL · 20 units | 0.1 mL · 10 units | 0.067 mL · 6.7 units |
| 300 mcg | 0.3 mL · 30 units | 0.15 mL · 15 units | 0.1 mL · 10 units |
| 500 mcg | 0.5 mL · 50 units | 0.25 mL · 25 units | 0.167 mL · 16.7 units |
| 700 mcg (trial dose at 70 kg) | 0.7 mL · 70 units | 0.35 mL · 35 units | 0.233 mL · 23.3 units |
Two warnings belong beside that chart. It only holds if your vial was mixed with exactly 3 mL; add 2 mL or 5 mL and every figure in it moves. And the 200 and 300 mcg rows are the commercial convention rather than a tested dose, as the next sections explain. Your pharmacy’s label and your prescriber’s instructions outrank any table. To run the numbers for your own vial size and water volume, use the reconstitution calculator, and for the water itself see bacteriostatic water for sermorelin.
What doses were used in sermorelin trials?
These are the only doses that show up in actual randomized or controlled sermorelin studies:
- Adults: 10 µg/kg body weight, subcutaneous, nightly, for roughly 16–20 weeks — the only controlled adult study with real (not just biomarker) outcomes [1].
- Children with growth hormone deficiency: 30 µg/kg/day or 60 µg/kg/day, subcutaneous. A trial that compared both doses directly against real GH found no additional growth benefit from doubling the dose — while real GH outperformed both [2]. See sermorelin vs. HGH for that full comparison.
- Children, continuous delivery: 60 ng/kg/minute via continuous subcutaneous infusion (a pump, not a bolus injection) for up to a year, in a small trial studying sustained pituitary responsiveness [3].
Every one of these is a pediatric or geriatric-cohort dose from a specific study population — none was tested in healthy adults using sermorelin the way it is marketed today.
Translating the trial dose into a number you can picture
| Body weight | Literature-dosed amount (10 µg/kg, adult trial) |
|---|---|
| 55 kg (121 lb) | ~550 mcg nightly |
| 70 kg (154 lb) | ~700 mcg nightly |
| 90 kg (198 lb) | ~900 mcg nightly |
This table is arithmetic on a single 1997 trial’s protocol, not a dosing recommendation. It is here so the trial dose stops being an abstract “10 µg/kg” and becomes a number you can compare against what you see marketed. Nobody has run a dose-ranging study to find out whether a lower or higher dose than this works better, worse, or the same in adults.
Why is the dose sellers market different from the trial dose?
Commercial sermorelin protocols commonly advertise nightly doses somewhere in the 200–300 microgram range, sometimes higher with titration over time. That figure reflects standard clinical and commercial practice — it is not sourced to any published dose-finding trial. No randomized controlled trial has tested sermorelin at commercially marketed dose levels in adults. No dose-response study exists to say whether that range is more, less, or equally effective compared to the one trial dose above. When a seller’s page presents a specific nightly microgram number as “the clinical dose,” no clinical trial actually established that number — it is a compounding-practice convention, not a research finding.
How many mL of sermorelin is one dose?
This is one of the most-searched dosage questions, and it does not have a universal answer, because it is not actually a dosing question — it is a concentration question, which is why the chart above is built per vial. Sermorelin is sold as a compounded, reconstituted powder. The microgram-to-milliliter conversion depends entirely on how much bacteriostatic water your specific vial was mixed with and what concentration your specific pharmacy formulated. A vial reconstituted to 2 mg/mL delivers a very different volume for the same microgram dose than one reconstituted to 5 mg/mL. There is no trial-verified or universal mL figure to give here. Any page that hands you a flat “0.2 mL is your dose” number without knowing your specific vial’s concentration is giving you a number that may not match what is actually in your syringe. Your own vial’s label and your pharmacy’s mixing instructions are the only inputs that make the conversion exact.
How much sermorelin should you take per day?
Every trial that showed a measurable outcome — the adult lean-mass and well-being result, the pediatric growth results — used a single nightly injection, not multiple daily doses [1][2][3]. The rationale connects back to the mechanism: nightly dosing is timed to work with the body’s natural nocturnal GH-release pattern. The one long-duration trial found sustained pituitary responsiveness without needing multiple daily pulses to keep working [3]. There is no controlled evidence behind splitting sermorelin into multiple daily doses.
What is the sermorelin dose for muscle growth?
There is no muscle-specific dose: the only trial that measured body composition used the same 10 µg/kg nightly and found more lean mass in men only [1]. What that result does and does not support, and why no bodybuilding dose has ever been tested, is covered in sermorelin for muscle growth.
The bottom line
If you want the dose with an actual trial behind it: 10 µg/kg nightly, subcutaneous, is what produced the one documented adult body-composition benefit, in men only, over about four to five months. A seller’s dosing chart advertising 200–300 mcg (or more) nightly for general use or muscle building is standard commercial practice, not a number pulled from a controlled study. It has not been tested against the trial dose to see which performs better. Knowing which of those two categories a number falls into is the whole ballgame here. Sellers that publish an actual milligram dose are listed on the injections board. For contrast, the one FDA-approved drug in the class has a fixed labeled dose, set out in tesamorelin dosage and side effects.